Glial cell involvement in vascular occlusion of diabetic retinopathy
نویسندگان
چکیده
منابع مشابه
2223 Glial cell involvement in vascular occlusion of diabetic retinopathy
Twenty areas of retinal vascular occlusion from ten eyes of 6 diabetic patients were studied by immunohistochemistry to type IV collagen (basement membranes), von Willebrand factor (endothelial cells), and to glial fibrillary acid protein (glial cells) on serial sections. In all studied lesions immunoreactivity to type IV collagen and von Willebrand factor was confined to the retinal vascular w...
متن کاملGlial cell line-derived neurotrophic factor in the vitreous of patients with proliferative diabetic retinopathy.
G lial cell line–derived neurotrophic factor (GDNF) belongs to the neurotrophic factor family. GDNF functions are not restricted to neurons but are also implicated in glial cell development (1). We observed high expression levels of GDNF receptor family -component 2 (GFR 2) in epiretinal membranes (ERMs) in proliferative diabetic retinopathy (PDR), indicating the involvement of GFR 2 in ERM for...
متن کاملOBSERVATIONS Glial Cell Line–Derived Neurotrophic Factor in the Vitreous of Patients With Proliferative Diabetic Retinopathy
G lial cell line–derived neurotrophic factor (GDNF) belongs to the neurotrophic factor family. GDNF functions are not restricted to neurons but are also implicated in glial cell development (1). We observed high expression levels of GDNF receptor family -component 2 (GFR 2) in epiretinal membranes (ERMs) in proliferative diabetic retinopathy (PDR), indicating the involvement of GFR 2 in ERM for...
متن کاملGlial reactivity, an early feature of diabetic retinopathy.
PURPOSE To characterize early structural gliotic reactions in retinal Müller cells, astrocytes, and microglia in experimentally induced diabetes. METHODS Rats were rendered diabetic by streptozotocin injection and killed after 2, 4, 12, or 20 weeks. Cell densities were determined in flatmounted retinas or transverse semithin sections. Expression of glial fibrillary acidic protein (GFAP) was l...
متن کاملDiabetic Retinopathy: Vascular and Inflammatory Disease
Diabetic retinopathy (DR) is the leading cause of visual impairment in the working-age population of the Western world. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. Inflammation mediates structural and molecular alterations associated with DR. However, the molecular mechanisms underlying the inflammatory pathways associated with DR ...
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ژورنال
عنوان ژورنال: Acta Ophthalmologica Scandinavica
سال: 2009
ISSN: 1395-3907
DOI: 10.1111/j.1600-0420.1997.tb00764.x